Prognostic and Therapeutic Potential of the OIP5 Network in Papillary Renal Cell Carcinoma

Papillary renal cell carcinoma (pRCC) is an aggressive but minor type of RCC. The current understanding and management pRCC remain poor. We report here OIP5 being a novel oncogenic factor possessing robust prognostic values therapeutic potential. upregulation observed in pRCC. associated with adverse features (T1P < T2P CIMP, Stage1 + 2 Stage 3 4, N0 N1) effectively stratifies the fatality risk. promotes ACHN proliferation xenograft formation; latter correlated network alterations related to immune regulation, metabolism, hypoxia. A set differentially expressed genes (DEFs) was derived from xenografts primary pRCCs (n = 282) contingent upregulation; both DEG sets share 66 overlap genes. Overlap66 predicts overall survival (p × 10?16) relapse possibilities. High-risk tumors stratified by risk score possess suppressive environment, evident elevations Treg cells PD1 CD8 T cells. Upregulation PLK1 occurs elevations. displays synthetic lethality relationship OIP5. inhibitor BI2356 inhibits growth formed Collectively, can be explored for personalized therapies patients.